Active substance: Isotretinoin
Low dose isotretinoin to treat acne, has been tried previously. The higher values 96. Hermes et al.
None stopped treatment. Relapse is reported more frequently following treatment with a lower dose.
Relapse occurred in 16. Relapses were more common in females with polycystic ovarian disease.
These relapses controlled with topical therapy alone or combined with oral antibiotics. The relapse rate observed by us was lower than that of above mentioned studies. Table 3 Open in a separate window In a study by Amichai et al.
Patients at increased risk for early relapse included younger patients with acne of relatively recent onset, those with truncal acne, and women with polycystic ovary syndrome. In our study, relapse rate had not any relation with patient's weight, age, and anatomical location of lesions.
Safety was assessed during the study by the reporting of adverse events.
The most common side-effects in our study were mild cheilitis in 93 patients 66. The observed side-effects were mild, and only 6 patients discontinued study medication because of severe adverse events.
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