Active substance: Gabapentin
Here we assess efficacy and tolerability of gabapentin enacarbil GEn in adults with moderate-to-severe primary RLS, with or without prior DA exposure.
It is not recommended for RLS patients who need to sleep during the day and remain awake at night. Please see Important Safety Information below and the complete prescribing information available at. Once absorbed, it is converted into gabapentin, which binds to a specific type of calcium channel but does not exhibit affinity for other common receptors.
Horizant is not interchangeable with other gabapentin products because of differing pharmacokinetic profiles.
The same dose of Horizant results in different plasma concentrations of gabapentin relative to the same dose of other gabapentin products. Patients on Horizant should not drive until they have sufficient experience to know whether their ability to drive is impaired.
Patients should not drive or operate other complex machinery until they have sufficient experience on Horizant to know whether their ability to perform these tasks is impaired. The same dose of Horizant results in different plasma concentrations of gabapentin relative to other gabapentin products.
The safety and effectiveness of Horizant in patients with epilepsy have not been studied. AEDs increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking Neurontin for seizures without your doctor's advice, and tell your doctor right away if you become pregnant.
Gabapentin can pass into breast milk, but effects on the nursing baby are not known. Ask your doctor about any risk.
How should I take Neurontin? Take Neurontin exactly as prescribed by your doctor. Follow all directions on your prescription label.